Jared Padalecki and Jensen Ackles, alumni of successful youth-oriented fare on WB Network (Padalecki from "Gilmore Girls," Ackles from "Smallville"), co-star as Sam and Dean Winchester, brothers with an eerie family history. When they were small children, their mother perished in an incident that defied both the laws of gravity and combustion. In the opener, Dean persuades Sam to join him in a search for their father, who dropped out of sight during a recent spirit hunt.

Subscribe to the Hollywood Reporter and see the entertainment industry from its best angle: the inside looking out. Complete access to real-time news and exclusive analysis that goes behind the scenes from film to television, home video to digital media.

   Subscribe now.