The "Prison Break" gang will face a formidable nemesis next season to be played by "Invasion" star William Fichtner. The search for an actor to play the role went down to the wire and production on the show, on location in Dallas, had to be postponed by a day until the deal with Fichtner was finalized. "Vanished" chronicles the disappearance of a senator's (John Allen Nelson) wife through the eyes of an FBI agent (Gale Harold) and a reporter (Rebecca Gayheart).

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